In Lambert-Eaton myasthenic syndrome (LEMS), patients’ immune systems attack a critical nerve cell protein, causing muscle weakness and degeneration. But not always — some patients lack antibodies to this protein, the calcium channel. Using the Monte Carlo Cell (MCell) simulation software developed in collaboration with PSC, running on PSC’s Bridges-2 system, a team from the University of Pittsburgh and PSC identified several factors that may contribute to LEMS. The results may help explain the historically limited success in treating LEMS and point to possible better treatment strategies.
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